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Having returned from the north after finding nothing, Wolverine/Logan watches over the school students for a night as Charles Xavier visits Magneto in his plastic confinement prison and Storm and Jean Grey search for a teleporter mutant known as Nightcrawler who attempted to assassinate the president.
Things become deadly as William Stryker, a scientist who has experimented on mutants, leads a siege on Xavier's mansion- few mutants escape.
With the school no longer safe, Magneto out of prison and forming a temporary alliance with the X-Men, and Professor Xavier in the hands of Stryker; the mutants team up to stop Stryker's plans to wipe the mutants off the face of the Earth.